Besides the great biodiversity of their flora, South American countries have high potential for the production of great amount of raw material at low cost. Over the last 50 years, the demand for vegetal extracts has gradually increased, since they are natural sources of bioactive compounds that can be used in cosmetic, pharmaceutical and food industries, among others. Jackfruit leaves (Artocarpus heterophyllus) are rich in phenolic compounds, which give them powerful antioxidant, anti-inflammatory and antibacterial properties; however, there are few literature data available on jackfruit leaves extraction. Adding value to raw materials using ecologically correct technologies is ideal to increase income without degrading the environment. An alternative to fulfill those requirements is the extraction of volatile oils and oleoresins using supercritical technology. In spite of being a well-known clean technology, there is still no industrial unit operating with it in South America, because of the high investment costs. Low pressure solvent extraction (LPSE) still is the most used technology in industries for recovery of oleoresins; however, this process usually extracts complex crude mixtures, so that the steps of solvent removal and purification can elevate the final product cost. On the other hand, recent studies have shown that supercritical fluid extraction (SFE) may be economically viable to obtain extracts from vegetable matrices, presenting very low operational cost. The use of simulation softwares allows substantial cost, labor and time reduction in the studying of industrial processes. The objective of this work was to compare the economical viability of SFE towards LPSE of jackfruit leaves. Literature and laboratory data for SFE and LPSE, respectively, were used to estimate the cost of manufacturing (COM) of the extract. The simulation software SuperPro Designer 6.0® was used to determine the COM.