Carotenoids are a family of phytochemical compounds known by their performance in several areas for instance as biological colorant and antioxidant. Some of these compounds are precursor of vitamin A, thus, potentially protecting against some illness. These are probably the reasons for the intensification of the number of research to obtain carotenoids derived products, therefore, increasing on their market share and production. Due to its huge biodiversity, Brazil has numberless possibilities of growing in both the raw material production and manufacturing of vegetal extracts rich in bioactive compounds fields. In these circumstances, Palm (Elaes guineensis) and Buriti (Mauritia flexuosa), which have considerable quantities of carotenoids (5,000 ppm and 10,000 ppm, respectively) in their extract obtained via supercritical technology, become possible sources to explore for obtain these phytochemical compounds. Supercritical fluid extraction (SFE) is an environmentally safe technology, which is becoming popular in the most important world-wide markets. However, the use of this technology is not yet spread in industrial scale in South America. The main reason for this is the high investment cost associated with SFE processes. Therefore researches regarding the estimation of the cost of manufacturing (COM) and scale-up of the process become essential to introduce industrial scale SFE in this region. Process simulation has the advantage of reducing the time required to develop processes. The main objectives of this study was to verify the capability of SuperPro Designer® to estimate the COM of SFE carotenoids-rich extracts obtained from two palm trees that spontaneously growth in the Brazilian Amazonian region: Buriti and Palm. The COM of carotenoids obtained from the fruits of these two palm trees were estimated at 20 MPa and 313 K and 25 MPa and 328 K for buriti and palm, respectively. These conditions were selected from literature data.